A research team at NIT Rourkela has developed a patented bio-ink for 3D bioprinting, aimed at improving tissue engineering applications.
The newly developed bio-ink is designed to create tissue-like structures with improved performance. It addresses a key limitation in existing bio-inks by combining mechanical strength, biological compatibility, and printability in a single system. This balance has been a major challenge in expanding the practical use of 3D bioprinting technologies.
The research team, led by Prof. Devendra Verma along with Ms. Shreya Chrungoo and Dr. Tanmay Bharadwaj, created a high shape-fidelity protein–polysaccharide bio-ink. The formulation includes Bovine Serum Albumin, Sodium Alginate, and polyelectrolyte complexes of gelatin and chitosan. This combination supports cell growth while maintaining structural stability during and after printing.
Laboratory tests showed that the bio-ink mimics the extracellular matrix of bone tissue, enabling cell attachment and growth. Scaffolds developed using the material demonstrated strong mechanical properties and retained their structure effectively. Experiments also recorded over 90 percent cell viability in samples containing specific compositions, along with indications of bone tissue formation and collagen production.
The technology has been patented and published in an international journal. Researchers plan to move to animal studies next, followed by clinical validation to assess safety and effectiveness in real-world medical applications.
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